Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests
نویسندگان
چکیده
منابع مشابه
Developing standardized behavioral tests for knockout and mutant mice.
The ability to produce transgenic, knockout, and mutant mice provides new animal models for the genetic analysis of behavior and its underlying neural mechanisms (Chen and Tonegawa 1997; Wehner et al. 1996). Knockout and transgenic mice have been developed as animal models for the study of human diseases such as Alzheimer's disease (Flood and Morley 1998; Nalbantoglu et al. 1997), Down's syndro...
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BACKGROUND Patients with chronic pain frequently suffer affective disorders, particularly anxiety and depression. Although clinical research on the relationship between pain and depressive symptoms has been done, it is not clear whether pain causes depression or depression exaggerates pain. To investigate the relation between pain and affect, we measured anxiety and depression-related behaviors...
متن کاملPhenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2).
Galanin is a neuropeptide implicated in the regulation of feeding, reproduction, cognition, nociception, and seizure susceptibility. There are three known galanin receptor (GALR) subtypes (GALR1, GALR2, and GALR3), which bind to galanin with different affinities and have their own unique distributions, signaling mechanisms, and putative functions in the brain and peripheral nervous system. To g...
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ژورنال
عنوان ژورنال: Neuropeptides
سال: 2008
ISSN: 0143-4179
DOI: 10.1016/j.npep.2008.04.009